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NEW! The PhyloGeoTool realised by Rega inst. on EuResist data published and available online
The project EuResist (Integration of viral genomics with clinical data to predict response to anti-HIV treatment, IST-2004-027173) has been funded by the European Commission in 6th Framework Program. It was successfully completed in September 2008.
Its results have been transferred to Informapro and are:
• The largest HIV resistance database available. EuResist’s first key achievement was the creation of the EuResist Integrated Data Base (EIDB), which is now the largest database of HIV genotypes and clinical response available. It integrates data from the project partners (ARCA from Italy, AREVIR from Germany and Karolinska from Sweden), and has recently expanded with data coming from Luxembourg, Belgium (Leuven) and Spain (Badalona). The data collected include demographics, viral loads, CD4 counts, treatment history and HIV genotypes for more than 40.000 patients.
• EuResist Resistance prediction system. Three engines have been developed and found to perform similarly but not identically in validation tests. Techniques such as Support Vector Machines, Fuzzy logic, Case Based Reasoning, and Random Forests have been investigated, while finally all of the three engines have ended up with using Logistic Regression models for the classification of the therapies as successes or failures. However, the three engines use different approaches to derive such models from the EuResist database plus derived features providing extra information not directly contained in the standard datum.
InformaPRO owns the industrial property
Karolinska Institutet - SWEDEN
Max Planck - GERMANY
UniKoeln - GERMANY
UniSiena - ITALY
IBM Research Lab - ISRAEL
MTA KFKI Reszecske-ES Magfizikai KutatoIntezet - HUNGARY
Kingston University - UK